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Concentrations decline sharply with age: plasma levels drop from roughly 200 ng/mL at age 20 to under 80 ng/mL by age 60

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Presence of inorganic, or, especially, organic matrix usually changes the photodegradation rate, as a consequence of indirect photolysis

To address the critical issue of BBB permeability, studies using [H]Dihexa and [C]inulin in rats revealed that Dihexa avidly concentrated in all examined brain regions including the prefrontal cortex, hippocampus, hypothalamus, striatum, thalamus, midbrain, brain stem, and cerebellum, compared to blood